Major depressive disorder (MDD) also referred to the depression. Depression is a low mood disorder that is usually experienced for two weeks transversely most of the situations. Generally, complemented by the loss of on interest, low self-esteem, pain without a due cause, etc. people who experience this type of disorders may experience hearing things that others cannot hear or even have some false beliefs. However, some of the people, experience a separated depression within a year period whereas other the depressive disorder may be on a regular basis. About 3%, i.e. approx. 216 million of the world’s population is affected by major depressive disorder whereby females are double affected in comparison to males. The cause of this disorder is said to be changed in the environment, certain medications, family history, substance abuse and chronic health problems whereby 40% is related to genetics. Records show that between 2-7% of the adults experiencing depression mostly die of suicide whereby 60% of those die of suicide are said to have depression or another form mood disorder.In this study, I will analyze four articles that explain particular causes exist that lead to the clinical depression, be considered as the most complicated form of humans’ depression. The first, article explains that the block disorder contains a fundamental disturbances change effect on the mood to the depression (with or even without an assisted nervousness) or even to a delight (“ICD-10 Version: 2010”, 2018). Ideally, the disposition change is mostly conveyed with a variation in the entire level of commotion. Most of the experienced signs are subordinate to and even effortlessly agreed to the perspective of activity and mood variation. This disorder is always regular, and the start of distinct incidents is often associated with traumatic situations or an event.The second article discusses on clinical depression as a common but a severe type of disorder. Categorically, this article analyzes the various forms of depression that are slightly different but may develop under some unique circumstances (Richards & Hara, 2014). This includes the Psychotic depression, the Persistent depressive disorder, Seasonal affective disorder, Psychotic depression and bipolar disorder. The study goes ahead to discuss the signs and symptoms, The risk factors, treatment therapies, Medications, psychotherapies and brain stimulations therapies.Ideally, the study talks about clinical trials research that outlines new ways that are required to detect and detect the diseases and conditions that includes the depression. According to the discussion, the participants tend to receive the treatment that may include new drugs or even combination of drugs, new ways, new devices or procedures to be applied to the existing treatment. Mostly, the participants are the aid to enjoy the benefit of the part of the trial and should always be aware of the primary purpose of a clinical trial gain into a specific knowledge of that other may get more assistance in future.The third study specifically points out at suicide as a concern to the clinicians who work with the clients who experiences a major depressive disorder (MDD) (Link, B. G. 1987). The study reviews the data regarding the prevalence of the suicidal behavior to those with the depressive disorder. The articles hence examine the risk factors for the suicidal ideation, death, and self-injury. Also provides an empirical overview of the treatment thus aim to decrease the risk factor. Therefore, the study explains to the reader with a lot of wealth information that relates to the suicidal risk and the death risk. Most probably the treatment method reliably lead to a decrease in the suicide death that comes from depression. Indeed, a variety of challenges tend to confront the practitioners who work with both suicidal clients who include the turnout and fatigue litigation and anxiety. And even the humanitarian assistance to those under the risk factors. Therefore emphasizing on great approaches that will reduce the loss of their lives through depression that comes from suicidal.The fourth study analyzes the functionality and the wellbeing of the results from the depressed people in comparison to the chronic general medical sickness (Hayset, al, 1995). The study talks about depression as a unique factor that is related to the limits of well-being and the functionality that got equal or even great than those of the chronic in an overall condition in medicating like arthritis and diabetes. The study carried out some analysis for three-year observational research. This research was held I the year 1970for the adult outpatients experiencing the depression, heart failure, hypertension, diabetes and recent myocardial infarction. However, the study gives the results that indicated that the limitations and the functionality and the wellbeing had improvement on the depressed people although the restrictions were worse or similar to the people attributed onto the chronic medical illness. Hence, more severely the depressed patients had improvement and more in functioning although the initially depressed people without the depressive disordered experienced a substance persistence kind of limitations. The research indicated that the depressed patients had a long and substantial decrement in various functional domains and wellbeing that is equal or greater to those of the patients with the chronic medical illness.The Fifth study examines the effectiveness and safety of the two medications, i.e. riluzole ketamine when treating depressive disorder treatment resistant (research, 2016). The study furthermore cross-examines the efficacy of the approved FDA drug referred as the lamotrigine when decreasing various potential side effects that are associated with ketamine. Hence the study investigates on riluzole, glutamate agent on the treatment-resistant to the patients who indicate critical, maintained reply in a distinct dosage for the intravenous (IV) racemic ketamine. And fifty ketamine-responders have to be randomized to placebo or riluzole for one month period, double-blind, randomized, and continuation phase study.In conclusion, these studies have analyzed situations and factors that make clinical depression, be considered as the most complicated form of humans’ depression. Like any other disorder, Depression is high risk to the life of an individual, and hence much action needs to be taken by the community. Patients who experience this depression needs attention and adequate care by persons of good will to make their life come back to normal. Depressions are characterized by some discomforts like low self-esteem, poor thinking and even loss of interest. This creates a person brain functionality fail to reason responsibly hence risking personal life into the miserable conduct of affairs. Therefore clinical disorder is the change in mood for weeks or months.ReferencesHays, R. D., Wells, K. B., Sherbourne, C. D., Rogers, W., & Spritzer, K. (1995). Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Archives of general psychiatry, 52(1), 11-19.ICD-10 Version:2010. (2018). Apps.who.int. Retrieved 28 February 2018, from http://apps.who.int/classifications/icd10/browse/2010/en#/F30-F39Link, B. G. (1987). Understanding labeling effects in the area of mental disorders: An assessment of the effects of expectations of rejection. American Sociological Review, 96-112.Research, C. (2016). Research Study for Major Depressive Disorder: Investigation of Glutamate Medications – Full Text View – ClinicalTrials.gov. Clinicaltrials.gov. Retrieved 28 March 2018, from https://clinicaltrials.gov/ct2/show/study/NCT00419003Richards, C. S., & O’Hara, M. W. (Eds.). (2014). The Oxford handbook of depression and comorbidity. Oxford University Press.